【摘 要】
：
Selective detection of multiple analytes in a compact design with dual-modality and theranostic features presents great challenges. Herein, we wish to report a coumarin-thiazolidine masked D-penicillamine based dual-modality fluorescent probe COU-DPA-1 fo
【机 构】
：
State Key Laboratory of Bioengineering Reactor,Shanghai Key Laboratory of New Drug Design,and Shangh
论文部分内容阅读
Selective detection of multiple analytes in a compact design with dual-modality and theranostic features presents great challenges. Herein, we wish to report a coumarin-thiazolidine masked D-penicillamine based dual-modality fluorescent probe COU-DPA-1 for selective detection, differentiation, and detoxifi-cation of multiple heavy metal ions (Ag+ , Hg2+ , Cu2+ ). The probe shows divergent fluorescence (FL) /cir-cular dichroism (CD) responses via divergent bond-cleavage cascade reactions (metal ion promoted C-S cleavage and hydrolysis at two distinctive cleavage sites): FL“turn-off”and CD“turn-on”for Ag+ (no hydrolysis), FL“turn-on”and CD“turn-off”for Hg2+ (imine hydrolysis), and FL“self-threshold ratiomet-ric”and CD“turn-off”for excess Cu2+ (lactone and imine hydrolysis), providing the first example of a fluorescence/CD dual-modality probe for multiple species with complimentary responses. Moreover, the bond-cleavage cascade reactions also lead to the formation of D-penicillamine heavy metal ion complexes for potential detoxification treatments.
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