论文部分内容阅读
目的:探讨高血压患者血浆N末端脑钠肽原(NT-proBNP)浓度与高血压程度是否相关,以及NT-proBNP能否作为判断高血压严重程度的客观生化指标。方法:入选2006年9月至2007年6月,在我院门诊就诊和住院的高血压患者共115例,年龄32～90岁,平均(65.1±10.7)岁,对高血压患者进行分级,通过心电图、心脏超声及临床表现进行左心室心功能评估;采集患者的静脉血用电化学发光免疫学方法检测血浆NT-proBNP浓度,所得数据采用SPSS11.5软件包进行统计学分析。结果:1、2级高血压与正常对照组间的NT-proBNP浓度差异无统计学意义(P>0.05);3级高血压比正常对照组的NT-proBNP浓度高,差异有统计学意义(P<0.05);高血压伴收缩性心力衰竭(心衰)患者血浆NT-proBNP浓度高于单纯高血压患者,差异有统计学意义(P<0.01)。结论:高血压患者血浆NT-proBNP浓度与高血压程度有一定关系,与高血压伴收缩性心衰相关性强。NT-proBNP可能会成为评估高血压疾病严重程度的生化指标之一。
Objective: To investigate whether plasma N-terminal pro-brain natriuretic peptide (NT-proBNP) concentration is associated with the severity of hypertension and whether NT-proBNP can be used as an objective biochemical index to determine the severity of hypertension. Methods: From September 2006 to June 2007, a total of 115 hypertensive patients were hospitalized and hospitalized in our hospital, aged from 32 to 90 years (mean, 65.1 ± 10.7 years). Hypertensive patients were classified by ECG, echocardiography and clinical manifestations of left ventricular cardiac function assessment; collected venous blood of patients with plasma chemiluminescence immunoassay NT-proBNP plasma concentration, the data obtained using SPSS11.5 software package for statistical analysis. Results: There was no significant difference in NT-proBNP between grade 1 and 2 hypertension (P> 0.05). The NT-proBNP concentration of grade 3 hypertension was higher than that of control group (P <0.05) P <0.05). The plasma concentration of NT-proBNP in hypertensive patients with systolic heart failure (HF) was higher than that in patients with hypertension alone (P <0.01). Conclusion: The plasma concentration of NT-proBNP in patients with hypertension has a certain relationship with the degree of hypertension, which is closely related to hypertensive patients with systolic heart failure. NT-proBNP may be one of the biochemical markers for assessing the severity of hypertension.