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目的了解27～43岁育龄期妇女对4种邻苯二甲酸酯类(phthalic acid di-ethyl esters,PAEs)的暴露情况。方法选择宁夏医科大学总医院生殖中心体检的30名育龄妇女为研究对象,采集静脉血样本,采用高效液相色谱法测定血清中的邻苯二甲酸二甲酯(DMP)、邻苯二甲酸二乙酯(DEP)、邻苯二甲酸二丁酯(DBP)和邻苯二甲酸二(2-乙基己基)酯(DEHP)和黄体生成素(LH)、卵泡刺激素(FSH)、睾酮(T)、雌二醇(E2)水平。结果育龄期妇女血清中DMP的检出率为76.67%(含量为未检出～0.37μg/L,中位数为0.13μg/L),DBP的检出率为56.67%(含量为未检出～1.24μg/L,中位数为0.07μg/L),DEHP的检出率为20.00%(含量为未检出～0.26μg/L,中位数为未检出);LH、FSH、T、E2的浓度分别为(5.60±4.24)IU/L,(6.59±2.90)IU/L,(44.60±20.19)pg/ml,(35.35±20.26)ng/ml。DMP、DBP、DEHP与激素水平之间无显著相关性和趋势关系(均P>0.05)。结论本次调查的宁夏地区育龄期妇女血清中PAEs污染物目前以DMP和DBP为主。
Objective To investigate the exposure of four kinds of phthalic acid di-ethyl esters (PAEs) in women of childbearing age from 27 to 43 years old. Methods Thirty women of childbearing age who underwent physical examination at the Reproductive Center of General Hospital of Ningxia Medical University were enrolled in this study. Venous blood samples were collected. The contents of dimethyl phthalate (DMP), bis (DEP), dibutyl phthalate (DBP) and di (2-ethylhexyl) phthalate (DEHP) and luteinizing hormone (LH), follicle stimulating hormone (FSH), testosterone T), estradiol (E2) levels. Results The detection rate of DMP in serum of women of childbearing age was 76.67% (the content was undetected ~ 0.37μg / L, the median was 0.13μg / L), the detection rate of DBP was 56.67% (the content was undetected ~ 1.24μg / L, the median was 0.07μg / L), the detection rate of DEHP was 20.00% (the content was undetected ~ 0.26μg / L, the median was not detected); LH, FSH, T , And the concentrations of E2 were (5.60 ± 4.24) IU / L, (6.59 ± 2.90) IU / L, (44.60 ± 20.19) pg / ml and (35.35 ± 20.26) ng / ml respectively. DMP, DBP, DEHP and hormone levels between the no significant correlation and trend (all P> 0.05). Conclusion PAEs in sera of women of childbearing age in Ningxia are mainly DMP and DBP.