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目的 探讨过敏性紫癜性肾炎 (APN)与脂质过氧化及抗氧化的关系。方法 采用化学分析法检测 18例APN患儿的相关指标。结果 APN急性期患儿血清脂质过氧化物 (LPO)增高 ;全血超氧化物歧化酶 (SOD)、谷胱甘肽过氧化物酶 (GSH - px)、谷胱甘肽 (GSH)降低 (P均 <0 0 1) ;恢复期时 ,LPO和SOD仍与对照组有显著差异 (P均 <0 0 5 ) ,而GSH -px、GSH与对照组无显著差异 (P均 >0 0 5 ) ;相关分析显示 :LPO与SOD无显著相关 (r =0 2 4,P >0 0 5 ) ,LPO与GSH - px、GSH、C3 呈显著负相关 (r =- 0 83,P <0 0 1;r =- 0 72 ,P <0 0 1;r=- 0 5 7,P <0 0 5 )。结论 APN患儿脂质过氧化增强 ,抗氧化机能下降。LPO、SOD、GSH -px、GSH等 4项指标可用以判断病情变化 ,且以GSH - px为最灵敏
Objective To investigate the relationship between allergic purpura nephritis (APN) and lipid peroxidation and antioxidation. Methods The chemical indicators were used to detect 18 children with APN. Results The levels of serum lipid peroxides (LPO) were increased in acute APN patients. The levels of superoxide dismutase (SOD), glutathione peroxidase (GSH - px) and glutathione (GSH) (P <0.01). LPO and SOD were still significantly different from those in the control group during recovery (all P <0.05), while there was no significant difference between GSH-px and GSH in control group 5). Correlation analysis showed that there was no significant correlation between LPO and SOD (r = 0 2 4, P 0 05) and LPO was negatively correlated with GSH - px, GSH and C3 (r = - 0 83, P 0 0 1; r = - 0 72, P <0 0 1; r = - 0 5 7, P <0 0 5). Conclusion APN children with lipid peroxidation increased, anti-oxidation function decreased. LPO, SOD, GSH-px, GSH and other four indicators can be used to determine the changes in the disease, and the most sensitive to GSH - px