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探索了镉致肝损伤的脂质过氧化机制及锌、硒单独和同时作用对镉致肝毒性的拮抗机理。结果表明，镉中毒组大鼠肝匀浆丙二醛（ＭＤＡ）含量、总超氧化物歧化酶活力（Ｔ－ＳＯＤ）、谷胱甘肽过氧化物酶活性（ＧＳＨ－Ｐｘ）以及肝组织中锌、硒、镉三元素含量均与对照组有显著性差异（Ｐ＜０．０５），而镉锌组、镉硒组、镉锌硒组中上述各指标均与镉组有显著性差异（Ｐ＜０．０５）；且显示肝组织中锌、硒、镉含量分别与组织Ｔ－ＳＯＤ活力、ＧＳＨ－Ｐｘ活性及ＭＤＡ含量呈正相关关系（ｒ１＝０．８９４，Ｐ＜０．０５；ｒ２＝０．７８４、Ｐ＜０．０５；ｒ３＝０．８３２，Ｐ＜０．０５），提示锌、硒对镉所引起的肝的脂质过氧化具有拮抗作用。
The mechanism of lipid peroxidation induced by cadmium-induced liver injury and the antagonistic mechanism of zinc and selenium alone and simultaneously on the hepatotoxicity induced by cadmium were explored. The results showed that malondialdehyde (MDA) content, total superoxide dismutase (T-SOD), glutathione peroxidase (GSH-Px) and liver tissue The content of three elements of zinc, selenium and cadmium were significantly different from that of the control group (P <0.05), while those of the cadmium-zinc group, the cadmium-selenium group and the cadmium zinc-selenium group were all significantly different from that of the control group P <0.05). The contents of zinc, selenium and cadmium in liver tissue were positively correlated with T-SOD activity, GSH-Px activity and MDA content (r1 = 0.894, P <0.05; r2 = 0.784, P <0.05; r3 = 0.832, P <0.05), suggesting that zinc and selenium have an antagonistic effect on liver lipid peroxidation caused by cadmium.