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目的 通过在海南省开展消除新生儿破伤风的研究,为我国制订消除新生儿破伤风策略与措施提供科学依据。方法 用回顾性和PPS调查方法调查NT死亡率、育龄妇女TT接种率、抗体水平;开展NT病例监测,对育龄妇女进行TT突击接种并与儿童常规免疫系统同时运行,开展广泛的社会动员。结果 三亚、琼中NT发病率逐年下降,2001年三亚已降到1.07‰,琼中县达到0.92‰,育龄妇女TT3针累计接种率达到95.1%、97.8%,育龄妇女TAT水平血清学监测结果与接种率调查结果一致,育龄妇女TT1针接种后可产生保护水平TAT,并且有51%的人可维持13个月左右,在符合最短间隔条件下,不同免疫间隔TAT差异没有显著统计学意义。建议 将育龄妇女TT接种与计划生育工作密切挂钩,在育龄妇女领取计划生育指标时,必须出示TT接种证,使育龄妇女TT接种工作可持续发展。
Objective To provide a scientific basis for our country to formulate policies and measures to eliminate neonatal tetanus by carrying out the study on eliminating neonatal tetanus in Hainan Province. Methods The retrospective and PPS survey methods were used to investigate NT mortality and TT vaccination rates and antibody levels in women of childbearing age. To carry out surveillance of NT cases, TT vaccination was carried out in women of childbearing age and the routine immune system of children was operated simultaneously to carry out extensive social mobilization. Results In Sanya and Joan, the incidence of NT decreased year by year. In 2001, the incidence of NT decreased to 1.07 ‰ and that of Qiongzhong County reached 0.92 ‰. The total TT3 needle-vaccination rate reached 95.1% and 97.8% in women of childbearing age. The results of TAT serological surveillance Inoculation rate survey results, women of childbearing age after TT1 needle can produce protection level TAT, and 51% of people can maintain about 13 months, meet the shortest interval conditions, different immunization interval TAT difference was not statistically significant. It is suggested that TT vaccination of women of childbearing age should be closely linked with family planning work. When women of childbearing age receive family planning indexes, TT vaccination certificates must be presented so that the TT vaccination work of women of childbearing age can sustainably develop.