白塞病合并周围神经病变(法国)

• 作 者: Ben Ghorbel I. Ibnelhadj Z. Zouari M. 方伯言
• 机 构: Service de Médecine Interne Hpital La Rabta 1007 Tunis Tunisia,
• 出 处: 世界核心医学期刊文摘(神经病学分册)
• 发表日期: 2005年08期
• 关键词: 周围神经病变 白塞病 神经滋养血管 神经病 勃起功能障碍 神经活检 感觉异常 结肠镜检查 肌无力 周围神经

Introduction. The involvement of the peripheral nervous system in Behet’s d isease is very rare. Case report. We report a case of a 47-year-old man with a six-year history of Behet’s disease and a two-year history of peripheral n ervous system involvement. This patient presented with paraesthesia and weakness of the upper and lower limbs, diarrhea and erectile dysfunction. The electromyo gram showed evidence of an axonal sensorimotor neuropathy and the nerve biopsy s howed an axonal neuropathy. Routine blood tests were normal, there was no increa se of serum creatine kinase, aspartate aminotransfease or lactate dehydrogenase and no signs of hyperthyroidism. Fibroscopy and colonoscopy showed no signs of e ntero-Behet.The patient was treated with prednisone, cyclophosphamide and car bamazepine with an improvement of paraesthesia. Conclusion. The mechanism of the peripheral neuropathy in Behet’s disease is still unknown, it might be due t o vasculitis of the vasa nervorum or to the side effects of colchicine. Our repo rt is particular by the association of sensorimotor and autonomic involvement of peripheral neuropathy in a patient with Behet’s disease.

Introduction. The involvement of the peripheral nervous system in Behet’s d isease is very rare. Case report. We report a case of a 47-year-old man with a six-year history of Behet’s disease and a two-year history of peripheral n ervous system involvement. This patient presented with paraesthesia and weakness of the upper and lower limbs, diarrhea and erectile dysfunction. The electromyo gram showed evidence of an axonal sensorimotor neuropathy and the nerve biopsy s howed an axonal neuropathy. Routine blood tests were normal, there was no increa se of serum creatine kinase, aspartate aminotransfease or lactate dehydrogenase and no signs of hyperthyroidism. Fibroscopy and colonoscopy showed no signs of e ntero-Behet. The patient was treated with prednisone, cyclophosphamide and car bamazepine with an improvement of paraesthesia. Conclusion. The mechanism of the peripheral neuropathy in Behet’s disease is still unknown, it might be due to vasculitis of the vasa nervorum or t o the side effects of colchicine. Our repo rt is particularly by the association of sensorimotor and autonomic involvement of peripheral neuropathy in a patient with Behet’s disease.