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众所周知,肝星状细胞(hepatic stellate cell,HSC)的激活及细胞外基质(extracellular matric,EMC)的大量产生是肝纤维化的中心环节。因此,寻找促进肝星状细胞凋亡的途径是防治肝纤维化的重要策略。本文就目前对HSC凋亡机制的研究做一综述。一、肝星状细胞凋亡的常见通路1.死亡受体介导的凋亡通路死亡受体(death receptors,DR)是细胞表面一类能结合胞间凋亡刺激分子并可将信号传至胞内引起细胞凋亡的受体,隶属于肿瘤坏死因子受体(TNDR)超家族。其结构上含有
It is well-known that the activation of hepatic stellate cells (HSC) and the massive production of extracellular matrices (EMCs) are central to hepatic fibrosis. Therefore, looking for ways to promote hepatic stellate cell apoptosis is an important strategy for prevention and treatment of liver fibrosis. This article summarizes the current research on apoptosis mechanism of HSC. First, the common pathway of hepatic stellate cell apoptosis 1. Death receptor-mediated apoptosis pathway Death receptors (DR) is a type of cell surface that can bind to the apoptotic molecules and can signal to Receptors that cause intracellular apoptosis are subordinate to the tumor necrosis factor receptor (TNDR) superfamily. Its structure contains