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目的：为探索增殖细胞核抗原（ＰＣＮＡ）和ｐ２１在喉非典型增生与其转化后的鳞癌中的表达有无差异。方法：用ＡＢＣ免疫组化技术对３７例分别来自同一患者的喉非典型增生和鳞癌及７例正常喉组织进行了ＰＣＮＡ、ｐ２１检测。结果：ＰＣＮＡ和ｐ２１的表达在喉癌与非典型增生间均有统计学差异；由非典型增生至癌，其ＰＣＮＡ指数升高的有３０对；正常喉组织的ＰＣＮＡ指数显著低于喉病变组织，ｐ２１染色阴性。结论：ｐ２１的过度表达与喉非典型增生和喉癌的发生有关，高ＰＣＮＡ指数对喉癌的诊断与鉴别诊断有一定的辅助价值
Objective: To explore whether PCNA and p21 expression are differentially expressed in atypical hyperplasia of the larynx and their transformed squamous cell carcinoma. Methods: ABC immunohistochemistry was used to detect PCNA and p21 in 37 cases of atypical hyperplasia of the larynx and squamous cell carcinoma of the larynx in 7 cases and 7 cases of normal laryngeal tissue. Results: The expressions of PCNA and p21 were significantly different between laryngeal carcinoma and atypical hyperplasia. From atypical hyperplasia to carcinoma, the PCNA index increased 30 pairs. The PCNA index in normal laryngeal tissues was significantly lower than that in laryngeal lesions , P21 staining negative. Conclusion: The overexpression of p21 is associated with atypical hyperplasia of the larynx and the occurrence of laryngeal carcinoma. The high PCNA index has some auxiliary value in the diagnosis and differential diagnosis of laryngeal carcinoma