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目的探讨硬化性上皮样纤维肉瘤(SEF)的临床病理学特征。方法对2012年3月收治的l例SEF患者进行组织学观察、免疫组织化学检查并复习相关文献。结果 SEF主要以细胞质透亮的上皮样肿瘤细胞伴大量透明变性胶原纤维为特征,瘤细胞排列主要呈条索状、巢状。肿瘤细胞波形蛋白阳性表达,细胞角蛋白和平滑肌肌动蛋白阴性表达。结论 SEF是一种较为罕见的软组织肿瘤,应注意与一些具有上皮样形态和硬化性间质的肿瘤相鉴别。
Objective To investigate the clinicopathological features of sclerosing epithelioid fibrosarcoma (SEF). Methods One case of SEF treated in March 2012 was studied by histology, immunohistochemistry and review of relevant literature. Results SEF was mainly characterized by cytoplasmic translucent epithelial tumor cells with a large number of transparent degenerative collagen fibers. The arrangement of tumor cells was predominantly cord-like and nested. Tumor cell vimentin positive expression, cytokeratin and smooth muscle actin negative expression. Conclusions SEF is a relatively rare soft tissue tumor, and should be distinguished from some tumors with epithelial-like morphology and sclerotic stroma.