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系统性红斑狼疮属自身免疫性疾病。其病因不明,多倾向于C型RNA病毒感染,引起免疫活性细胞的突变,使免疫系统失去控制,及T、B细胞不平衡。有人作动物试验证实,有遗传易感性,其内源性为亲代遗传传递而来。遗传在病因中起着重要作用。发病多为一级血缘亲属,同卵双胎尤甚。有报告本病似有家族性。本文报告两例家族性系统性红斑狼疮。说明本病的发生确与遗传内源性及免疫缺陷有关。
Systemic lupus erythematosus is an autoimmune disease. The etiology is unknown, more prone to C RNA virus infection, causing the mutation of immunocompetent cells, the immune system out of control, and T, B cell imbalance. Some animal experiments confirmed that there is genetic susceptibility, its endogenous genetic transmission from the parents. Genetics plays an important role in the cause. Mostly related to the level of relatives, especially twins identical. There are reports of the disease seems familial. This article reports two cases of familial systemic lupus erythematosus. That the occurrence of this disease is indeed related to genetic endogenous and immune defects.