【摘 要】
：
骨关节炎（OA）是一种由多因素导致的骨关节疾病，严重威胁人类健康，其主要表现为关节疼痛、功能障碍，严重者可致畸形。OA的机制尚不十分明确，且缺少有效的治疗药物；针对OA病因、发病机
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骨关节炎（OA）是一种由多因素导致的骨关节疾病，严重威胁人类健康，其主要表现为关节疼痛、功能障碍，严重者可致畸形。OA的机制尚不十分明确，且缺少有效的治疗药物；针对OA病因、发病机制及预防措施的探索一直是该领域的重要研究方向。有研究发现，转化生长因子-β（TGF-β）/Smad信号通路在OA的发生和发展过程中起着关键作用。本文就近年来国内外关于TGF-β/Smad信号通路在OA中作用的研究进展进行综述。“,”Osteoarthritis (OA) is a bone and joint disease caused by multiple factors, which seriously threatens human health. It is mainly manifested as joint pain and dysfunction. In severe cases, it can cause deformity. The mechanism of OA is not very clear, and there is a lack of effective therapeutic drugs; the exploration of etiology, pathogenesis and preventive measures of OA has always been an important research direction in this field. Studies have found that the transforming growth factor-β (TGF-β)/Smad signaling pathway plays a key role in the occurrence and development of OA. This article reviews the research progress of TGF-β/Smad signaling pathway in OA in recent years at home and abroad.
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