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慢性粒细胞白血病(以下简称慢粒)并发低纤维蛋白原血症的出血是非常罕见的,文献中仅报导过一次(Br Med J 1:495～496,1975)。作者报导1例低纤维蛋白原血症的出血是慢粒患者死亡的主要原因。患者男,57岁。三年前确诊为慢粒。患病后不用化疗时,外周血白细胞波动在20,000～150,000。因恶心、呕吐、衰弱和不适三天伴前额部头痛加剧住院。血压170/90毫米汞往,脉搏88次/分,呼吸20次/分,不发热。眼底检查有动脉变狭。心脏闻及S_4心音。肝脾轻度肿大。神经系统检查无明显异常。大便及鼻胃管抽出液隐血试验均阳性。血红蛋白13.3克。红细胞客积45%。白细胞577,000,原始细胞15%,中幼粒细胞13%,晚幼粒细胞14%,杆状核粒细胞10%和分叶核粒细胞21%。血
Bleeding of chronic myelogenous leukemia (CML) with hypofibrinogenemia is rare and reported only once (Br Med J 1: 495-496, 1975). The authors report that 1 case of low fibrinogen bleeding is the main cause of death in patients with chronic particles. Male patient, 57 years old. Three years ago diagnosed as slow granules. Without chemotherapy, the peripheral blood leukocytes fluctuate between 20,000 and 150,000. Nausea, vomiting, weakness and discomfort for three days with exacerbations intensified hospitalization. Blood pressure 170/90 mm mercury, pulse 88 beats / min, breathing 20 beats / min, no fever. Fundus examination with arterial narrowing. Heart smell S_4 heart sound. Liver and spleen mild swelling. Nervous system examination no obvious abnormalities. Stool and nasogastric tube extract occult blood test were positive. Hemoglobin 13.3 grams. Egg white matter 45%. 577,000 white blood cells, 15% primitive cells, 13% of neutrophils, 14% of late promyelocytic cells, 10% of rod-like nuclei and 21% of segmented neutrophils. blood