论文部分内容阅读
目的探讨高尿酸血症与代谢综合征的危险因素。方法采用病例-对照研究方法 ,选择教师人群中符合高尿酸血症(HUA)诊断标准的病例(Ⅰ组)60例,既符合HUA诊断标准又符合代谢综合征(MS)的病例(Ⅱ组)60例,同时选择同期体检的健康者60例作为对照,采用统一调查问卷对其进行现场调查,内容包括体检人群的一般情况、生活习惯(吸烟情况、饮酒情况、体力活动)、饮食习惯(采用食物频率法和7天膳食记录法)、家族史等情况,并进行体检和实验室检测。结果单因素Logistic回归分析结果 ,体质指数(BMI,OR=1.520,95%CI:1.295~1.783)、收缩压(SBP,OR=1.045,95%CI:1.016~1.074)、舒张压(DBP,OR=1.064,95%CI:1.020~1.111)、总胆固醇(TC,OR=4.198,95%CI:2.289~7.700)、甘油三酯(TG,OR=42.852,95%CI:11.245~163.302)、空腹血糖(FPG,OR=1.412,95%CI:1.281~1.603)、高密度脂蛋白胆固醇(HDL-C,OR=3.017,95%CI:1.706~5.338)、饮茶(OR=3.727,95%CI:1.750~7.938)、食海鲜(OR=2.266,95%CI:1.125~2.569)及血脂异常家族史(OR=1.248,95%CI:1.116~2.532)与HUA有关联。MS不仅与以上因素相关,而且还与饮啤酒(OR=1.314,95%CI:1.137~2.722)、食蔬菜(OR=6.571,95%CI:2.942~14.680)、食水果(OR=5.035,95%CI:2.319~10.930)及高血压病史(OR=1.183,95%CI:1.084~2.400)有关。多因素Logistic回归分析结果显示,BMI及TG是HUA及MS共同的独立危险因素。结论高尿酸血症与代谢综合征的成分(肥胖、血脂紊乱、高血压)密切相关。
Objective To investigate the risk factors of hyperuricemia and metabolic syndrome. Methods A case-control study was conducted to select 60 cases of the HUA (diagnostic criteria for hyperuricemia) in the teacher population (group Ⅰ), which met the diagnostic criteria of HUA and met the metabolic syndrome (group Ⅱ) 60 cases. At the same time, 60 healthy people were selected as the control group. The questionnaires were used to conduct on-the-spot investigation, which included the general situation of the medical examination population, living habits (smoking, drinking, physical activity) Food frequency and 7-day dietary records), family history and other conditions, and physical examination and laboratory testing. Results The results of univariate logistic regression showed that body mass index (BMI, OR = 1.520, 95% CI: 1.295-1.783), systolic blood pressure (SBP, OR = 1.045, 95% CI: 1.016-1.074) = 1.064, 95% CI: 1.020-1.1111), total cholesterol (TC, OR = 4.198, 95% CI: 2.289-7.700), triglyceride (TG, OR = 42.852, 95% CI: 11.245-163.302) Blood glucose (OR = 1.412, 95% CI: 1.281-1.603), high density lipoprotein cholesterol (HDL-C, OR = 3.017, 95% CI: 1.706-5.338) (OR = 2.266, 95% CI: 1.125-2.569) and family history of dyslipidemia (OR = 1.248, 95% CI: 1.116-2.532) were associated with HUA. MS was not only related to the above factors, but also with beer (OR = 1.314, 95% CI: 1.137-2.722), vegetables fed (OR = 6.571,95% CI: 2.942-14.680) % CI: 2.319 ~ 10.930) and history of hypertension (OR = 1.183, 95% CI: 1.084 ~ 2.400). Multivariate Logistic regression analysis showed that BMI and TG were independent risk factors of HUA and MS. Conclusion Hyperuricemia is closely related to the components of metabolic syndrome (obesity, dyslipidemia, hypertension).