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A rat model of spinal cord injury was established using modified Allen’s method and treated with the ferric iron-chelating agent,deferoxamine.Hematoxylin-eosin,Nissl and Perl’s Prussian blue staining,at 7-14 days following spinal cord injury,showed that following deferoxamine treatment,glial cells proliferation increased significantly,nerve cell morphology was improved and hemosiderin was significantly reduced in the injury region.At 1-56 days following injury,Basso,Beattie,and Bresnahan Locomotor Rating Scale scores were increased,while latencies of somatosensory-evoked potentials and motor-evoked potentials were decreased.Results demonstrate that deferoxamine can promote neurological functional recovery after experimental spinal cord injury in rats.
A rat model of spinal cord injury was established using modified Allen’s method and treated with the ferric iron-chelating agent, deferoxamine. Hematoxylin-eosin, Nissl and Perl’s Prussian blue staining, at 7-14 days following spinal cord injury, showed that following deferoxamine treatment, glial cells proliferation increased significantly, nerve cell morphology was improved and hemosiderin was significantly reduced in the injury region. At 1-56 days following injury, Basso, Beattie, and Bresnahan Locomotor Rating Scale scores were increased, while latencies of somatosensory-evoked potentials and motor-evoked potentials were decreased. Results demonstrate that deferoxamine can promote neurological functional recovery after experimental spinal cord injury in rats.