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[目的]探讨动脉灌注治疗中晚期头颈部肿瘤的临床意义。[方法]近2年收治的36例中晚期的头颈部肿瘤病人,进行化疗药物动脉灌注治疗,肿瘤越过中线的超选到两侧颈外动脉灌注,对于有明显动静脉瘘病变的用明胶海绵颗粒栓塞后再灌注,灌注的化疗药物为卡铂100mg、吡柔比星20mg、氟尿酐500mg、拓僖10mg;以上药物分别用生理盐水或5%的葡萄糖水稀释至120ml。[结果]总共灌注268次,最多灌注18次,最少的灌注4次,36例患者症状均不同程度地缓解;在治疗过程中出现了相关的并发症4例次。[结论]对于中晚期头颈部肿瘤的患者进行化疗药物的联合动脉灌注,在缓解患者的疼痛症状,改善吞咽功能方面是有效的,在治疗过程中部分患者可能发生严重的神经系统并发症,不可忽视。
[Objective] To investigate the clinical significance of arterial infusion in the treatment of advanced head and neck cancer. [Methods] Thirty-six patients with advanced head and neck cancer treated in the recent 2 years were treated with chemotherapeutic drug arterial infusion. The tumor was surgically displaced by midline to both sides of the external carotid artery. For animals with obvious arteriovenous fistula lesions, Sponge particles embolization after reperfusion, perfusion of chemotherapy drugs carboplatin 100mg, pirarubicin 20mg, fluorouracil 500mg, Tuo Tuo 10mg; above drugs were diluted with saline or 5% glucose water to 120ml. [Results] A total of 268 injections, with a maximum of 18 injections, with a minimum of 4 injections, relieved symptoms to varying degrees in 36 patients; 4 associated complications occurred during the course of treatment. [Conclusion] The combined arterial infusion of chemotherapeutic drugs for patients with advanced head and neck cancer is effective in alleviating pain symptoms and improving swallowing function in patients with advanced head and neck cancer. In the course of treatment, some patients may experience serious neurological complications, Can not be ignored.