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据报道,对乙型肝炎疫苗无应答的尿毒症患者,在接种疫苗的同时给予白细胞介素2(IL-2),可产生抗-HBs.血液透析病人有罹患病毒性肝炎的危险,这些病人对乙型肝炎疫苗应答低(或无),通常是由于免疫抑制或可能是由于单核细胞功能缺陷所致.作者对41例患者(Ⅰ组)只接种40μg酵母源性乙型肝炎疫苗,对另40例患者(Ⅱ组)在0、1和6个月接种疫苗时加用2MU重组γ干扰素(IFN-γ),这些患者均经长期的血液透析,并患有不同类型的肾病,但未接触乙型肝炎病毒或接种过疫苗.结果第Ⅱ组
It has been reported that in patients with uremia who do not respond to hepatitis B vaccine, interleukin 2 (IL-2) is administered simultaneously with the vaccine to produce anti-HBs. Hemodialysis patients are at risk of developing viral hepatitis, and these patients The low (or no) response to hepatitis B vaccine is usually due to immunosuppression or may be due to defects in monocyte function. The authors inoculated 41 patients (group I) with only 40 [mu] g of yeast-derived hepatitis B vaccine against Another 40 patients (group II) received 2MU of recombinant interferon gamma (IFN-γ) at 0, 1, and 6 months of vaccination, all of whom had long-term hemodialysis and had different types of nephropathy, No contact with hepatitis B virus or vaccination Results Group II