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目的 与对照药氯雷他定片比较,评价盐酸氮(?)斯汀片治疗变应性鼻炎的临床疗效及安全性。方法 用多中心、随机、双盲、平行对照的临床试验,试验组变应性鼻炎病人58例,每日服用盐酸氮(?)斯汀片2次,每次1 mg;对照组病人63例,每日口服氯雷他定片1 0 mg和安慰剂各1次。两组均连续服药14天。对治疗前后的喷嚏、流涕、鼻堵、鼻痒及鼻腔情况进行评分。结果 盐酸氮革斯汀片和氯雷他定片治疗变应性鼻炎的有效率分别为87.93％,82.54％;药物不良反应发生率分别为8.62％,14.06％。经统计学检验,两者差异均无显著性。 结论 盐酸氮(?)斯汀片治疗变应性鼻炎安全有效。
Objective To compare the clinical efficacy and safety of loratadine tablets in the treatment of allergic rhinitis with nitrogen monoxide hydrochloride tablets. Methods In a multicenter, randomized, double-blind, parallel-controlled clinical trial, 58 patients with allergic rhinitis in the experimental group were treated with nitrogen monoxide hydrochloride twice daily for 1 mg each, and 63 patients in the control group , Daily loratadine tablets 10 mg and placebo 1 times. Both groups took 14 consecutive days. Before and after treatment of sneeze, runny nose, nasal congestion, nasal itching and nasal conditions were scored. Results The efficacies of nalustine hydrochloride tablets and loratadine tablets in the treatment of allergic rhinitis were 87.93% and 82.54%, respectively. The incidences of adverse drug reactions were 8.62% and 14.06% respectively. The statistical test showed no significant difference between the two. Conclusion Hydrochloride nitrogen (?) Sting tablets safe and effective treatment of allergic rhinitis.