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目的探讨脑出血后早发性癫痫发生的相关危险因素。方法选择脑出血患者259例,根据脑出血后2周内是否出现癫痫发作,分为癫痫组(33例)和非癫痫组(226例),收集其临床资料,包括神经影像学及脑电图学表现,分析影响脑出血后早发性癫痫发生的相关因素。结果单因素分析表明,癫痫家族史、围生期因素、每日饮酒≥100ml、每日吸烟≥40支、致痫药物史、高血压史、皮层出血、多病灶出血、出血量大、异常脑电图或出现癫痫样波均与脑出血后早发性癫痫的形成有关,差异有统计学意义(P<0.05)。多因素分析表明,脑出血后早期出现癫痫样波、出血灶多、每日吸烟量较大、具有癫痫家族史等是影响脑出血后早期癫痫发生的重要危险因素。结论脑出血后早期出现癫痫样波、出血灶多、每日吸烟量较大、具有癫痫家族史是癫痫发生的重要危险因素。
Objective To explore the related risk factors of early-onset epilepsy after intracerebral hemorrhage. Methods A total of 259 patients with intracerebral hemorrhage (ICH) were enrolled in this study. According to whether epileptic seizures occurred within 2 weeks after intracerebral hemorrhage, the patients were divided into epilepsy group (n = 33) and non-epileptic group (n = 226). The clinical data including neuroimaging and electroencephalogram Learning performance, analysis of related factors of early onset of epilepsy after cerebral hemorrhage. Results Univariate analysis showed that family history of epilepsy, perinatal factors, daily drinking ≥ 100ml, daily smoking ≥ 40, epileptic drug history, history of hypertension, cortical bleeding, multiple lesion bleeding, bleeding, abnormal brain Electrocardiogram or epileptiform wave were associated with the formation of early-onset epilepsy after intracerebral hemorrhage, the difference was statistically significant (P <0.05). Multivariate analysis showed that there were epileptiform waves in the early post-cerebral hemorrhage, more hemorrhagic foci and larger amount of cigarettes smoked per day. Having a family history of epilepsy was an important risk factor of early epilepsy after intracerebral hemorrhage. Conclusion Epileptiform wave occurs early after cerebral hemorrhage, with more hemorrhagic foci and more daily smoking. Having a family history of epilepsy is an important risk factor for epilepsy.