论文部分内容阅读
[目的]探讨Ki-67、ER和PR在子宫腺肌病中的表达及生物学意义。[方法]采用免疫组化法检测Ki-67、ER和PR在子宫腺肌病增殖期异位内膜和在位内膜、不典型增生、正常子宫内膜及子宫内膜癌中的组织定位和表达强度。[结果]子宫腺肌病的异位内膜腺体中Ki-67表达(40/46)高于在位内膜腺体(30/46),P<0.05。Ki-67的表达子宫腺肌病的异位内膜(40/46)、子宫内膜不典型增生(21/23)及子宫内膜癌(20/23)等病变的腺体组织中,均明显高于正常内膜(2/22),P<0.01。ER和PR在子宫腺肌病在位内膜腺体中的表达分别为41/46和41/46,分别高于其在异位内膜的表达32/46和33/46;异位内膜间质中PR表达(30/46)低于在位内膜间质(44/46),差异有显著性意义(P<0.01)。[结论]Ki-67异常表达与子宫腺肌病异位内膜的过度增殖和子宫内膜瘤变关系密切,而ER、PR的低表达及Ki-67表达的增高与子宫内膜的侵袭性生长有关。
[Objective] To investigate the expression and biological significance of Ki-67, ER and PR in adenomyosis. [Methods] Immunohistochemical method was used to detect the tissue localization of Ki-67, ER and PR in ectopic endometrium and in eutopic, dysplasia, normal endometrium and endometrial carcinoma during the proliferative phase of adenomyosis And expression intensity. [Results] The expression of Ki-67 in ectopic glandular adenomyosis (40/46) was higher than that in eutopic gland (30/46), P <0.05. Ki-67 expression in adenomyosis ectopic endometrium (40/46), endometrial dysplasia (21/23) and endometrial cancer (20/23) and other lesions of the glandular tissue, both Significantly higher than the normal endometrium (2/22), P <0.01. The expression of ER and PR in eutopic endometrium was 41/46 and 41/46, respectively, which were higher than those in eutopic endometrium, 32/46 and 33/46 respectively. Ectopic endometrium The expression of PR in stroma (30/46) was lower than that in eutopic stroma (44/46), the difference was significant (P <0.01). [Conclusion] The abnormal expression of Ki-67 is closely related to the hyperproliferation and endometrial neoplasia of ectopic endometrium of adenomyosis, while the low expression of ER and PR and the increase of Ki-67 expression and the invasion of endometrium Growth related.