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目的:研究伤科止痛膏抗炎作用及其机理。方法:采用小鼠二甲苯性耳肿胀,大鼠蛋清性足肿胀和棉球性肉芽肿等多种炎症模型观察本品抗炎作用;建立大鼠慢性软组织损伤模型,分别应用伤科止痛膏及扶他林乳膏涂布患处,并于治疗7天后取材并匀浆,采用放射免疫法测量匀浆液PGE2含量。结果:伤科止痛膏可明显抑制小鼠二甲苯性耳肿胀,显著抑制大鼠蛋清性足肿胀和棉球性肉芽组织增生,能显著抑制大鼠慢性软组织损伤后受伤局部PGE2含量的升高。结论:伤科止痛膏有明显的抗炎作用,其治疗慢性软组织损伤的疗效机理之一是抑制受伤局部PGE2含量升高。
Objective: To study the anti-inflammatory effect and mechanism of Shangke Zhitong Ointment. Methods: The mouse anti-inflammatory activity of xylene-induced ear swelling, rat paw edema and cotton ball granuloma were observed. The model of chronic soft tissue injury in rats was established. Fufarin cream coating the affected area, and in the treatment of 7 days after drawing and homogenate, measured by radioimmunoassay PGE2 content. Results: Injury and analgesic cream can significantly inhibit xylene ear swelling in mice, significantly inhibit rat paw edema and granulosa granulation tissue hyperplasia, can significantly inhibit the injury of chronic soft tissue injury in rats increased local PGE2 content. Conclusion: Injury analgesic cream has obvious anti-inflammatory effect. One of the therapeutic mechanisms for treating chronic soft tissue injury is to inhibit the increase of local PGE2 content in injured area.