有症状的胃食管反流病中埃索美拉唑抑酸能力比奥美拉唑更强

• 作 者: Lind T Rydberg L Kyreback A Jonsson A Andersson T Hasselgren G Holmberg J Rohss K 钟捷
• 机 构: Department of Surgery,Karnsjukhuset,Skovde,Department of Surgery,Karnsjukhuset,Skovde,Department of
• 出 处: 中华消化杂志
• 发表日期: 2002年09期
• 关键词: 埃索美拉唑 胃食管反流 症状学 反流物 药代动力学 酸相关性疾病 抑酸作用 抗酸药物 洗脱期 反流症状

目前已知胃反流物的侵袭力 (以黏膜损害程度表示 )及胃食管反流病 (ＧＥＲＤ)的相关症状对 ｐＨ值有高度依赖性。认为胃内ｐＨ =4是鉴别反流有无侵袭力的分界点。ｐＨ 4的反流物中含有活性的胃蛋白酶 ,可引起明显临床症状。将胃内 ｐＨ值提高到 4以上 ,是有效治疗ＧＥＲＤ的关

It is known that the invasion of gastric reflux (expressed as mucosal damage) and the associated symptoms of gastroesophageal reflux disease (GERD) are highly pH dependent. Stomach pH = 4 is considered as a demarcation point to identify the presence or absence of invasiveness of reflux. Refluxed pH 4 contains active pepsin, can cause significant clinical symptoms. Increasing the intragastric pH to more than 4 is an effective treatment for GERD