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目的 :探讨聚维酮联合吡柔比星膀胱灌注预防浅表膀胱癌复发的抗肿瘤免疫效果。方法 :选择5 2例浅表膀胱癌患者 ,采用术前 2 4～ 4 8h及术后灌注。观察组 34例 ,运用聚维酮作为吡柔比星的溶剂行膀胱灌注化疗。对照组 18例 ,运用生理盐水作为吡柔比星的溶剂行膀胱灌注。镜下观察两组肿瘤切除标本间质中的淋巴细胞分布并计数 ,免疫组化法检测S 10 0和CD2 8的表达。结果 :观察组淋巴细胞的计数、S 10 0和CD2 8表达明显高于对照组 (P <0 .0 5 )。结论 :免疫细胞集结分布和增强表达提示聚维酮可能增强机体的抗肿瘤免疫。
Objective: To investigate the anti-tumor immune effect of povidone combined with pirarubicin in preventing bladder cancer recurrence. Methods: Fifty-two patients with superficial bladder cancer were selected. The patients were treated 24-48 h before operation and postoperatively. The observation group of 34 cases, the use of povidone as pirarubicin solvent bladder irrigation chemotherapy. Control group of 18 cases, the use of saline as pirarubicin solvent bladder irrigation. The distribution and counting of lymphocytes in the interstitial of tumor resected specimens were observed under microscope, and the expressions of S 10 0 and CD 8 8 were detected by immunohistochemistry. Results: The counts of lymphocytes in the observation group were significantly higher than those in the control group (P <0.05). CONCLUSION: Immunocyte assembly distribution and enhanced expression suggest that povidone may enhance the body’s anti-tumor immunity.