论文部分内容阅读
高剂量甲氨蝶呤广泛应用于治疗恶性肿瘤,酮基布洛芬等非甾体类抗炎药对解除癌症患者的疼痛有效,两者同时使用,但其相互作用未见报道。本文回顾了5年来用高剂量甲氨蝶呤治疗36例肿瘤患者共118次,发现在9次严重毒性反应中有4次是同时服用酮基布
High-dose methotrexate is widely used in the treatment of malignant tumors. Ketoprofen and other non-steroidal anti-inflammatory drugs are effective in relieving pain of cancer patients. Both of them are used simultaneously, but their interactions have not been reported yet. This review of 5 years with high-dose methotrexate treatment of 36 patients with a total of 118 cases of cancer found in 9 of the 9 serious toxic reactions are taking ketuprofen