Ursodeoxycholic acid treatment improves hepatocyte ultrastructure in rat liver fibrosis

• 作 者: Nuket Mas Ilker Tasci Bilgin Comert Ramazan Ocal Mehmet Refik Mas
• 机 构: epartment of Anatomy Kocatepe University,School of Medicine,Afyon,Turkey,Department of Internal Medi
• 出 处: World Journal of Gastroenterology
• 发表日期: 2008年07期
• 关键词: Rat liver fibrosis Rat liver cirrhosis Ursodeoxycholic acid Electron microscopy

AIM: To examine the ultrastructural changes after ursodeoxycholic acid (UDCA) treatment in hepatocytes from experimentally induced fibrotic livers.METHODS: Liver fibrosis was induced in male Sprague-Dawley rats with CCl4 for 12 wk, and the rats were divided into two groups. Group I was treated with saline and group Ⅱ with UDCA (25 mg/kg per day) for 4 wk. All the rats were killed at wk 16. Mitochondria, nuclei, rough endoplasmic reticulum (RER) and smooth endoplasmic reticulum (SER) of hepatocytes were evaluated according to a scoring system.RESULTS: Mitochondria, nuclei, RER and SER injury scores in group Ⅱ were significantly lower than those in groupⅠ(P < 0.001). CONCLUSION: UDCA alleviates hepatocyte organelle injury in CCl4-induced liver fibrosis.

AIM: To examine the ultrastructural changes after ursodeoxycholic acid (UDCA) treatment in hepatocytes from experimentally induced fibrotic livers. METHODS: Liver fibrosis was induced in male Sprague-Dawley rats with CCl4 for 12 wk, and the rats were divided into two groups. Group All rats were killed at wk 16. Mitochondria, nuclei, rough endoplasmic reticulum (RER) and smooth endoplasmic reticulum (SER) of hepatocytes (I) treated with saline and group II with UDCA (25 mg / kg per day) RESULTS: Mitochondria, nuclei, RER and SER injury scores in group Ⅱ were significantly lower than those in group Ⅰ (P <0.001) CONCLUSION: UDCA alleviates hepatocyte organelle injury in CCl4-induced liver fibrosis.