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研究淋巴结阴性乳腺癌标本中组织蛋白酶－Ｄ（ｃａｔｈｅｐｓｉｎ－Ｄ）的含量及其预后价值。方法应用生化法检测１９８例乳腺癌标本中组织蛋白酶－Ｄ的含量，结合统计学生存率分析和单个相互因素分析方法，研究其在患者预后中的作用。结果（１）１９８例乳腺癌标本中，１６２例淋巴结阴性，３６例淋巴结阳性，淋巴结阳性标本中组织蛋白酶－Ｄ的含量要高于淋巴结阴性者。（２）１６２例淋巴结阴性患者中组织蛋白酶－Ｄ低表达患者的总生存率和无病生存率要高于中、高表达者。（３）组织蛋白酶－Ｄ的含量高低是唯一能对乳腺癌总生存率和无病生存率有提示作用的预后指标。结论应用生化法检测淋巴结阴性乳腺癌标本中组织蛋白酶－Ｄ的含量是临床判断患者预后的重要指标。
To study the cathepsin-D content and its prognostic value in lymph node negative breast cancer specimens. Methods The biochemical method was used to detect the content of cathepsin-D in 198 breast cancer specimens. Combined with the statistical survival analysis and the single mutual factor analysis method, the role of cathepsin-D in the prognosis of patients was studied. Results (1) Of the 198 breast cancer specimens, 162 were negative and 36 lymph nodes were positive. Cathepsin-D levels in lymph node positive specimens were higher than those in lymph node negative specimens. (2) The overall survival and disease-free survival of patients with low expression of cathepsin-D in 162 cases of lymph node-negative patients were higher than those with medium-high expression. (3) The level of cathepsin-D was the only prognostic indicator of the overall survival and disease-free survival of breast cancer. Conclusion The use of biochemical methods to detect the content of cathepsin-D in lymph node negative breast cancer specimens is an important indicator of clinical prognosis.