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Objective:To investigate the expression of cyclooxygenase-2(COX-2)and p16 proteins in non-Hodgkin’s lym-phomas(NHL)and their relationship with the genesis and progress of it.Methods:The expression of COX-2 and p16 protein were studied in the lymph nodes tissue from 60 NHL patients and 10 control patients with non-malignant diseases by flow cytometry.Results:Positive rate of COX-2 protein expression in NHL tissues(63.3%,38/60)was higher than that in normal lymphaden tissues(0,0/10).The difference was significant between the two groups(P < 0.01).Expression of COX-2 protein was related with the clinical stage of NHL.In stage I + II patients,it was significantly lower(35.0% + 54.6%)than that in stage III + IV patients(84.6% + 87.5%)(P < 0.01).In different sex,age,tumor malignant degree,IPI grade,extranodal involvement and B symptoms groups,the differences of COX-2 expression were not statistically significant(P > 0.05).Positive rate of p16 protein expression(41.7%,25/60)in NHL’ was statistically lower than that in normal lymphomas(100%,10/10)(P < 0.01).Expression of p16 protein was related to malignant degree of NHL.The positive rates of p16 protein in low malignant degree tissues(64.7%,11/17)was higher than that in high malignant degree tissues(14.3%,2/14)(P < 0.05).Positive rates of p16 protein of NHL tissues in different sex,age,IPI grade,extranodal involvement,clinical stages and B symptoms were not statistically significant(P > 0.05).The p16 protein expression in COX-2 positive patients was 47.4%(18/38),and in negative patients it was 31.8%(7/22).There was no statistically difference between them(P > 0.05).Correlation analysis revealed there was no correlation between expression of COX-2 and p16 protein.Conclusion:Both COX-2 and p16 protein may all have relationship with the genesis and progress of NHL.The expression of COX-2 protein in NHL may be a poor prognostic indicator.COX-2 and p16 protein probably have different mechanisms in the genesis and progress of NHL.Their relationship is firstly put forward in this article and needed further studying.
Objective: To investigate the expression of cyclooxygenase-2 (COX-2) and p16 proteins in non-Hodgkin’s lym-phomas (NHL) and their relationship with the genesis and progress of it. Methods: The expression of COX-2 and p16 protein were studied in the lymph nodes tissue from 60 NHL patients and 10 control patients with non-malignant diseases by flow cytometry. Results: Positive rate of COX-2 protein expression in NHL tissues (63.3%, 38/60) was higher than that in The difference was significant between the two groups (P <0.01) .Expression of COX-2 protein was related with the clinical stage of NHL. stage I + II patients, it was significantly lower (35.0% + 54.6%) than that in stage III + IV patients (84.6% + 87.5%) (P <0.01) .In different sex, age, tumor malignant degree, IPI grade, extranodal involvement and B symptoms groups, the The differences of COX-2 expression were not statistically significant (P> 0.05) .Positive rate of p16 protein expression (41.7%, 25/60) in NHL ’was statist Expression of p16 protein was related to malignant degree of NHL. The positive rates of p16 protein in low malignant degree tissues (64.7%, 11/10) were significantly lower than those in normal lymphomas 17) was higher than that in high malignant degree tissues (14.3%, 2/14) (P <0.05) .Positive rates of p16 protein of NHL tissues in different sex, age, IPI grade, extranodal involvement, clinical stages and B symptoms were not statistically significant (P> 0.05). The p16 protein expression in COX-2 positive patients was 47.4% (18/38), and in negative patients it was 31.8% (7/22) (P> 0.05) .Correlation analysis revealed there was no correlation between expression of COX-2 and p16 protein.Conclusion: Both COX-2 and p16 protein may all have relationship with the genesis and progress of NHL. The expression of COX-2 protein in NHL may be a poor prognostic indicator. COX-2 and p16 protein probably have different mechanisms in the genesis and progress of NHLTheir relationship is first put forward in this article and needed further studying.