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本文测定了五类实验性高血压大鼠三个脑区中二种脑啡肽的含量。在两肾两夹及两肾“8”结扎—盐高血压大限脑干,下丘和纹状体中甲脑啡肽(MEK)和亮脑啡肽(LEK)含量显著高于正常大鼠。在一肾一夹大鼠中除纹状体MEK及下丘LEK增加外,EK含量无显著变化。在两肾“8”结扎大鼠中仅脑干MEK稍有增加。DOCA—盐高血压大鼠与上述几种大鼠不同,它们的脑干和纹状体中EK含量虽然增加,而下丘MEK却明显下降,DOCA—盐大鼠中的这些变化随DOCA—盐处理时间延长而变得更加显著。结果提示以水纳潴留为特征的高血压动物中涉及中枢EK的含量改变。此外,DOCA对下丘MEK含量可能有重要作用。
In this paper, we measured the content of two enkephalins in three brain regions of five types of experimental hypertensive rats. MEK and LEK were significantly higher in brainstem, inferior colliculus and striatum than those in normal rats in two renal and two kidneys and two renal “8” ligation-salt hypertensive brain stem. There was no significant change in EK content except for MEK in the striatum and LEK in the inferior colliculus in a rat with one kidney and one clamp. Mesenteric MEK increased only slightly in both kidney “8” ligation rats. In DOCA-salt hypertensive rats, unlike the above-mentioned rats, their EK levels in the brainstem and striatum increased, while the MEK in the inferior colliculus decreased markedly, and these changes in DOCA-salt rats varied with DOCA-salt Processing time becomes longer and more significant. The results suggest that there is a change in the central EK content in hypertensive animals characterized by water retention. In addition, DOCA may have an important role on the hypothalamic MEK content.