论文部分内容阅读
目的探讨肾组织微循环变化在ＩｇＡ肾病（ＩｇＡＮ）发病机理中的作用。方法５５例ＩｇＡＮ肾穿标本的ＰＡＳＭ－Ｍａｓｓｏｎ染色片，用图像分析仪分别测定其中肾小球和肾小管的毛细血管内血浆平均吸光度，红细胞面积密度，以及毛细血管床面积密度。结果在ＩｇＡＮ病变各期，肾小球和肾小管的毛细血管内血浆吸光度和红细胞面积密度均显著升高，毛细血管床面积密度均明显降低。结论肾单位毛细血管内血浆蛋白和红细胞淤积，毛细血管床减少等病变存在于ＩｇＡＮ的整个过程中，是ＩｇＡＮ持续进展的重要因素
Objective To investigate the role of changes in renal microcirculation in the pathogenesis of IgA nephropathy (IgAN). Methods PASM-Masson staining of 55 cases of I-gAN kidney was used to measure the average plasma capillaries absorbance, erythrocyte area density and capillary bed area density of glomeruli and tubules with image analyzer respectively. Results At each stage of IgAN, the plasma absorbance and erythrocyte area density of glomeruli and tubules were significantly increased, and the capillary bed area density was significantly decreased. Conclusions Nephron capillaries plasma protein and red blood cell deposition, capillary bed reduction and other lesions exist in the I gAN whole process is an important factor in the continued progress of IgAN