论文部分内容阅读
目的评价~(99)Tc~m-奥曲肽显像在淋巴瘤中的临床应用价值。方法 11名健康志愿者和30例淋巴瘤患者进行~(99)Tc~m-奥曲肽显像。所有患者均进行了体格检查,胸部和腹、盆部 CT,颈部和腹股沟 B 超检查,部分完成了腹、盆腔 B 超检查(11例),~(67)Ga-枸橼酸盐全身显像(5例)和骨髓检查(8例)。结果在志愿者中,~(99)Tc~m-奥曲肽可使脑垂体、鼻咽部、甲状腺、肝、脾、双肾、膀胱、胆囊、消化道等组织器官显影,骨骼和骨髓区内放射性分布明显低下或缺损。在30例患者中,~(99)Tc~m-奥曲肽显像发现22例阳性,其中2例为淋巴结炎性反应性增生疾病。其诊断患者的灵敏度和特异性分别为83.3%(20/24)和4/6,假阴性率为16.7%(4/24);诊断病灶的灵敏度为49.3%(72/146);对膈肌上区和膈肌下区淋巴瘤病灶的诊断灵敏度分别为51.6%(48/93)和45.3%(24/53)。显像发现4个假阳性病灶,对病灶的诊断特异性为99.6%(990/994)。结论 ~(99)Tc~m-奥曲肽显像探测淋巴瘤病灶的灵敏度较低;其无法对恶性淋巴瘤和淋巴结炎性反应性增生进行鉴别。
Objective To evaluate the clinical value of ~ (99) Tc m-octreotide imaging in lymphoma. Methods Totally 99 Tc m-octreotide imaging was performed in 11 healthy volunteers and 30 patients with lymphoma. All patients underwent physical examination, chest, abdomen and pelvic CT, neck and groin B-ultrasound and partial abdominal and pelvic ultrasound (11 cases) and ~ (67) Ga-citrate whole body Like (5 cases) and bone marrow examination (8 cases). Results In volunteers, ~ (99) Tc ~ m-octreotide could promote the development of pituitary, nasopharynx, thyroid, liver, spleen, kidney, bladder, gallbladder, digestive tract and other tissues and organs, Distribution was significantly lower or defect. In 30 patients, ~ (99) Tc ~ m-octreotide imaging showed positive in 22 cases, of which 2 were lymphoid inflammatory hyperplasia. The diagnostic sensitivity and specificity were 83.3% (20/24) and 4/6, respectively. The false negative rate was 16.7% (4/24). The diagnostic sensitivity was 49.3% (72/146) The diagnostic sensitivities of the lesions in the region and subphrenic lymphoma were 51.6% (48/93) and 45.3% (24/53), respectively. Four false-positive lesions were visualized and the diagnostic specificity for lesions was 99.6% (990/994). Conclusions ~ (99) Tc m-octreotide imaging has a low sensitivity for detection of lymphoma lesion; it can not distinguish malignant lymphoma from inflammatory reactive hyperplasia of lymph node.