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目的 通过总结 1985～ 1989年与 1995～ 1999年医院感染金黄色葡萄球菌及耐甲氧西林金黄色葡萄球菌(MRSA)的情况 ,了解其在医院感染中的耐药性变迁 ,为进一步控制其在医院的暴发流行提供可靠的实验室依据。方法 对从住院患者各种临床标本中分离出的金黄色葡萄球菌 ,用 K- B法检测 MRSA。结果 金黄色葡萄球菌医院感染株从 1985年的 34 .4%上升到 1989年的 6 0 .0 % ,MRSA从 1985年的 18.6 %上升到 1989年的33.3% ,两者均有上升趋势 (P<0 .0 5 ) ;1995～ 1999年医院感染金黄色葡萄球菌及 MRSA未见呈上升趋势 (P>0 .0 5 ) ,但感染率均高于 1985～ 1989年。结论 80年代中后期医院感染金黄色葡萄球及 MRSA呈逐年上升趋势 ,但进入 90年代中后期相对稳定 ,这可能和重视及开展医院感染有着密切关系
Objective To summarize the prevalence of nosocomial infections of Staphylococcus aureus and methicillin-resistant Staphylococcus aureus (MRSA) between 1985 ~ 1989 and 1995 ~ 1999 in order to understand the changes of drug resistance in nosocomial infections. Outbreaks of hospitals provide a reliable laboratory basis. Methods Staphylococcus aureus isolated from various clinical samples of hospitalized patients were detected by K-B method. Results The S. aureus nosocomial infection increased from 34.4% in 1985 to 60.0% in 1989. The MRSA increased from 18.6% in 1985 to 33.3% in 1989, both of which showed an upward trend (P <0. 0 5). There was no increase in hospital infection of Staphylococcus aureus and MRSA between 1995 and 1999 (P> 0.05), but the infection rate was higher than that of 1985-1989. Conclusions The hospital infection of Staphylococcus aureus and MRSA in the middle and late 1980s has been increasing year by year. However, it was relatively stable in the middle and late 1990s, which may be closely related to the emphasis on hospital infection