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食管癌是最具侵袭性的癌症之一,居全球恶性肿瘤病死率的第六位。全球约70%的食管癌患者在中国,食管鳞状细胞癌是最常见的病理类型(>90%)。目前,临床上对于食管鳞状细胞癌的早期诊断和治疗非常有限,患者5年生存率仅为10%。然而,直到目前对于导致食管鳞状细胞癌发病的完整基因组事件仍知之甚少。本组对158例食管鳞状细胞癌病例进行一次全面的基因组分析:其中17例食管鳞状细胞癌病例进行全基因组测序,71例进行外显子测序,在
Esophageal cancer is one of the most aggressive cancers, ranking sixth in the world in terms of cancer mortality. About 70% of esophageal cancer patients in China Esophageal squamous cell carcinoma is the most common pathological type (> 90%) in China. At present, the clinical diagnosis and treatment of esophageal squamous cell carcinoma is very limited. The 5-year survival rate of patients is only 10%. However, little is known about complete genome events that cause esophageal squamous cell carcinomas to date. This group of 158 cases of esophageal squamous cell carcinoma cases a comprehensive genome analysis: 17 cases of esophageal squamous cell carcinoma of the genome-wide sequencing, 71 cases of exon sequencing, at