论文部分内容阅读
目的 探讨肺癌组织中表皮生长因子受体 (EGFR)的表达水平及其临床意义。方法 采用免疫组化ABC法检测 3 9例肺良性疾病、95例原发性肺癌及癌旁肺组织中EGFR的表达水平。结果 非小细胞肺癌 (NSCLC)组织EGFR表达阳性率为 87.9% ( 80 / 91) ,肺良性病变肺组织为 10 .3 % ( 4/3 9) ,4例小细胞肺癌 (SCLC)无EGFR表达。在NSCLC中 ,距癌组织 3cm以内癌旁肺组织EGFR阳性率为6 3 .7% ( 5 8/ 91) ,6cm以远正常肺组织为 12 .1% ( 11/ 91)。结论 肺癌组织EGFR表达水平显著高于良性疾病肺组织 ,检测EGFR表达有助于肺部良恶性疾患的鉴别诊断。
Objective To investigate the expression and clinical significance of epidermal growth factor receptor (EGFR) in lung cancer. Methods Immunohistochemical ABC method was used to detect the expression of EGFR in 39 cases of benign lung disease, 95 cases of primary lung cancer and adjacent lung tissues. Results The positive expression rate of EGFR was 87.9% (80/91) in non-small cell lung cancer (NSCLC), 10.3% (4/39) in lung benign lung disease, and no EGFR expression in 4 cases of small cell lung cancer (SCLC). . In NSCLC, the positive rate of EGFR in para-tumoral lung tissue within 3 cm from the cancer tissue was 63.7% (58/91), and that in normal lung tissue was 6.1% (11/91). Conclusion The expression of EGFR in lung cancer tissues is significantly higher than that in benign lung tissues. Detection of EGFR expression is helpful for differential diagnosis of benign and malignant lung diseases.