论文部分内容阅读
一、背景库欣综合征(Cushing syndrome,CS)是由于垂体腺瘤(pituitary adenoma,PA)、异位ACTH肿瘤(ectopic ACTH-producting tumor,EAT)、肾上腺皮质增生或肿瘤(adrenal cortical hyperplasia or tumor,ACH/ACT)等引起的皮质醇增多所致的临床综合征。其中的一部分患者皮质醇分泌增多呈周期性或者呈间断不规则节律,导致典型的CS临床症状复杂化和变异化,这部分患者称为周期性库欣综合征(Cyclic Cushing Syndrome,Cyclic CS)[1]。皮质醇水平的波动存在于以下三种情况中:(1)皮质醇分泌的随机波动;(2)高皮质醇状态的自发缓解;(3)周期性CS。正常人的皮质醇分泌有昼夜节律、超日节律(Ultradian,周期<24 h)和亚日节律(Infradian,周期>24 h)。
Background Cushing syndrome (CS) is a disorder characterized by pituitary adenoma (PA), ectopic ACTH-producting tumor (EAT), adrenal cortical hyperplasia or tumor , ACH / ACT) and other clinical syndrome caused by increased cortisol. Some of these patients have increased cortisol secretion with periodic or intermittent irregular rhythms, leading to the complications and variability of typical CS clinical symptoms, a condition known as Cyclic Cushing Syndrome [Cyclic Cushing Syndrome 1]. Fluctuation in cortisol levels exists in three cases: (1) random fluctuations in cortisol secretion; (2) spontaneous remission of hypercortisol status; and (3) periodic CS. Normal human cortisol secretion circadian rhythm, ultra-day rhythm (cycle <24 h) and the rhythm (Infradian, cycle> 24 h).