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自从1853年阿斯匹林问世以来,它经历了一个多世纪的临床考验,至今仍作为主要的消炎、镇痛、解热药被广泛地应用着.1948年具有强大的抗炎作用的肾上腺皮质激素的出现,一时曾降低了阿斯匹林的身价,人们的注意力转到甾体激素抗炎剂的研究上.可时隔不久,就发现甾体抗炎药具有较多的副作用.为此,学者们又转事非甾体抗炎药的研究,并终于发现了保泰松.六十年代初,又相继发现了消炎痛,甲灭酸,布洛芬,更加激发了药物化学家对非甾体抗炎药的深入研究的积极性,从而取得了巨大的进展.本文拟就其目前发展的概况作简单的回顾.
It has undergone more than a century of clinical testing since the advent of aspirin in 1853 and is still widely used as a major antiinflammatory, analgesic and antipyretic drug. In 1948, adrenal cortex with a strong anti-inflammatory effect The emergence of hormones, once reduced the value of aspirin, people’s attention to the study of steroidal anti-inflammatory drugs may be soon after, we found that steroidal anti-inflammatory drugs have more side effects. As a result, scholars turned to non-steroidal anti-inflammatory drugs and finally found Phenylbutazone.6 In the early 1960s, they also found indomethacin, mefenamic acid and ibuprofen, which further stimulated drug chemists Great progress has been made in the enthusiasm of the non-steroidal anti-inflammatory drugs in-depth study.This paper will briefly review the current development of NSAIDs.