论文部分内容阅读
探讨了基苯酞（ｄｌ－３－ｎ－ｂｕｔｙｌｐｈｔｈａｌｉｄｅ，ｄｌ－ＮＢＰ）对大鼠蛛网膜下腔出血（ＳＡＨ）的可能治疗作用．方法：侧脑室注射自体动脉血造成蛛网膜下腔出血模型，氢清除法测定尾核局部脑血流（ｒＣＢＦ），结果：蛛网膜下腔出血后１５ｍｉｎ，ｒＣＢＦ即快速降至注血前的 ５２％，并且在 １８０ｍｉｎ内基本上维持在该水平．ｄｌ－ＮＢＰ ５０，１００ ｍｇ·ｋｇ－１（ｉｇ）皆可提高 ＳＡＨ后 ３０－１８０ ｍｉｎ内的 ｒＣＢＦ；而ｄｌ－ＮＢＰ１００ ｍｇ·ｋｇ－１在 １５ｍｉｎ时即可将ｒＣＢＦ提高２６％，１８０ｍｉｎ时达 ３６％．结果还发现 ｄ－ＮＢＰ （１０ｍｇ·ｋｇ－１， ｉｐ）提高ｒＣＢＦ，但ｌ－ＮＢＰ（１０ ｍｇ·ｋｇ－１， ｉｐ）则无明显作用．结论：丁基苯酞改善ＳＡＨ后ｒＣＢＦ。
The possible therapeutic effect of dl-3-n-butylphthalide (dl-NBP) on subarachnoid hemorrhage (SAH) in rats was investigated. Methods: Subarachnoid hemorrhage was induced by intracerebroventricular injection of autologous arterial blood and rCBF was measured by hydrogen scintillation. Results: After 15 minutes of subarachnoid hemorrhage, rCBF decreased rapidly to 52 %, And maintained substantially at that level within 180 min. rCBF within 30-180 min after SAH could be increased by dl-NBP 50 and 100 mg · kg-1 (ig), while rCBF could be increased by 26% at dl-NBP100 mg · kg-1 and 15% 36%. The results also found that d-NBP (10 mg · kg-1, ip) increased rCBF, but l-NBP (10 mg · kg-1, ip) had no significant effect. CONCLUSION: Butylphthalide improves rCBF after SAH.