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目的:总结经肾穿刺活检明确肾脏病理的原发性IgA肾病141例住院患儿中医证型与肾脏病理类型的关系。方法:对本组资料的141例患儿在肾穿刺活检前24h内进行中医辨证分型,分析中医类型与肾脏病理光镜和免疫荧光的关系。结果:中医证型:肺卫风热,迫血下行证47例,下焦湿热,迫血下行证29例,气阴两虚证26例,肝肾阴虚证26例,脾肾气虚证13例。5种中医证型的肾脏病理类型分布明显不同。5种中医证型的肾组织免疫荧光类型在单纯IgA型;IgA+G型;IgA+M型;IgA+G+M型的分布上无明显不同。结论:中医证型与IgA肾病肾组织病理之间存在相关性,探讨其关系可以促进对本病的认识,有利于及时对此类疾病的诊断、治疗进行中医干预。
OBJECTIVE: To summarize the relationship between TCM syndromes and pathological types of kidney in 141 hospitalized children with primary IgA nephropathy confirmed by renal biopsy. Methods: 141 cases of children in this group were diagnosed by TCM in 24 hours before renal biopsy, and the relationship between TCM types and pathological light microscope and immunofluorescence was analyzed. Results: TCM syndrome type: lung Wei wind heat, forced blood descending 47 cases, under the coke damp heat, blood pressure down in 29 cases, qi and Yin Deficiency Syndrome in 26 cases, liver and kidney yin deficiency syndrome in 26 cases, spleen and kidney qi deficiency syndrome in 13 cases . The distribution of the kidney pathology of the five kinds of TCM syndromes is obviously different. Immunofluorescence of kidney tissue of five kinds of TCM syndromes showed no obvious difference in the distribution of simple IgA type, IgA + G type, IgA + M type, IgA + G + M type. Conclusion: There is a correlation between syndromes of TCM and renal histopathology of IgA nephropathy. To explore the relationship between TCM syndrome and IgA nephropathy can promote the understanding of this disease and facilitate the timely intervention of Chinese medicine for the diagnosis and treatment of such diseases.