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在体内和体外实验中系统地观察了中药大黄对大鼠近端小管和髓袢升支粗段小管Ｎａ￣＋－ｋ￣＋ＡＴＰ酶活性的影响，发现大黄对此二节段肾小管Ｎａ￣＋－Ｋ￣＋ＡＴＰ酶均具有显著抑制作用，尤其是对髓袢升支粗段作用更为明显。大黄的作用随剂量增大而增强，５０ｍｇ／Ｌ大黄对髓袢升支粗段Ｎａ￣＋Ｋ￣＋ＡＴＰ酶活性的抑制率达４２．９％。体内应用大黄后，出现利钠、利尿效应。本实验结果进一步明确了大黄对残余肾肾小管高代谢的抑制作用。
In vitro and in vivo experiments systematically observed the rhubarb on the proximal tubule and the ascending branch of the rat Rattus tubule Na ~ + -k ~ + ATPase activity and found that rhubarb two tubules Na ~ + -K ~ + ATP enzyme had a significant inhibitory effect, especially for the medullary Ascending branch of the role of the more obvious. The effect of rhubarb increased with dose, and the inhibitory rate of rhubarb on the activities of Na ~ + K ~ + ATPase in the ascending branch of the medulla oblongata was 42.9%. After the application of rhubarb in vivo, there sodium, diuretic effect. The experimental results further clarify the rhubarb renal tubular residual metabolism of high inhibition.