论文部分内容阅读
本文采用d1-15-甲基前列腺素F_(2α)(下称PGF_(2α)与R_(2323)合并应用抗早孕36例。每日口服R_(2323)mg,连服4d,停药48h后,阴道内置入PGF_(2α)8mg,8h后肌注2mg,全疗程8h,有效率为97％;其效果与孕妇有无人流史、剖腹产史或子宫畸形等均无明显差异。引流时间为15±5h。用药前后及流产时血清β-hCG-RIA及孕酮RIA皆无明显变化。通过对制剂的改革,使药物缓慢释放,延长了作用时间。此法抗早孕的优点是简便、有效、引流时间短、副作用少,尤适用于子宫畸形,剖腹产史、人流史及哺乳期孕妇。
In this paper, d1-15-methyl prostaglandin F_ (2α) (hereinafter referred to as PGF_ (2α) and R_ (2323) combined anti-early pregnancy in 36 cases of oral administration of daily R 2323 mg, even for 4 days, 48 hours after drug withdrawal , Vaginal implanted PGF_ (2α) 8mg, 8h after intramuscular injection of 2mg, the whole course of 8h, the effective rate was 97%; its effect and pregnant women with no history of abortion, history of cesarean section or uterine malformation were no significant difference in drainage time of 15 ± 5h.The serum β-hCG-RIA and progesterone RIA had no significant changes before and after treatment and abortion.After the reform of the preparation, the drug was slowly released and the action time was prolonged.This method has the advantages of simple, effective, Short drainage time, less side effects, especially for uterine malformations, caesarean section history, abortion history and lactating pregnant women.