【摘 要】
：
目的探讨卡马西平加重癫癎失神发作的机制.方法13周龄雌性GEARS鼠14只分为2组,用微导管在双侧丘脑网状核(Rt)或丘脑腹侧基底核(VB)各注射0.2μL卡马西平(含卡马西平15 nMOL)
【机 构】
：
首都医科大学附属北京友谊医院,北京,100050
论文部分内容阅读
目的探讨卡马西平加重癫癎失神发作的机制.方法13周龄雌性GEARS鼠14只分为2组,用微导管在双侧丘脑网状核(Rt)或丘脑腹侧基底核(VB)各注射0.2μL卡马西平(含卡马西平15 nMOL)或溶剂.注射药物后即刻记录90 min脑电图并分析.结果在VB注射卡马西平与注射溶剂相比,脑电图癫癎失神发作的累积时间和频率明显增加(P=0.01,n=7和P=0.03,n=7).而在Rt注射卡马西平组与溶剂组比较,两组间各项指标均无统计学差异.结论在VB注射卡马西平可加重癫癎鼠的失神发作,而注射于Rt对其无影响.提示卡马西平加重癫癎鼠失神发作的神经解剖部位在VB.
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