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近些年来,经分子杂交分析证实,HBVDNA不仅存在于HBsAg阳性者的肝组织中,而且在一些HBsAg阴性的慢性肝病(有或无HBV抗体)患者的肝组织中也存在HBV DNA,但对这类病毒DNA的精确物理结构和病毒核酸序列的病原学意义尚不清楚。本文作者对1例HBsAg阴性的慢性肝病患者肝组织中HBV DNA的存在状
In recent years, molecular hybridization analysis confirmed that HBVDNA exists not only in the liver tissue of HBsAg-positive individuals but also in the liver tissue of some HBsAg-negative chronic liver disease patients (with or without HBV antibody) The exact physical structure of the virus-like DNA and the etiological significance of the viral nucleic acid sequence are not clear. The author of this article on a HBsAg-negative patients with chronic liver disease in the presence of HBV DNA