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基于独立成分分析方法分别采用3 z-scale和5 z-scale氨基酸结构描述符,建立了抗原肽与MHC分子(major histocompatibility complex,MHC)相互作用结合的定量构效关系模型.该两个模型训练集样本数是316,预测集样本数是786.结果表明:3z-scale模型的预测准确度和AUC值分别为70.3%,0.70;5 z-scale模型的预测准确度和AUC值分别为70.9%,0.79.本文建立CTL表位预测模型对进一步了解抗原肽与MHCI类分子相互作用机理具有一定的帮助.
Based on the independent component analysis methods, the structure-activity relationship models of antigenic peptides and MHC interactions were established by using 3 z-scale and 5 z-scale amino acid structure descriptors respectively.These two models were trained The number of sample sets is 316 and the number of prediction sets is 786. The results show that the prediction accuracy and AUC of 3z-scale model are 70.3% and 0.70 respectively, and the prediction accuracy and AUC of 5z-scale model are 70.9% , 0.79.The establishment of CTL epitope prediction model in this paper is helpful to further understand the mechanism of interaction between MHC class I antigen peptides and MHC class I molecules.