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自从克尿塞类药物应用于临床治疗高血压病以来,无论单独使用或与其他降压药物合并应用均有相当明显的降压能力;而且服用方便,鲜有副作用,故已成为一种广泛应用的降压药物。然其降压机制尚待阐明。有数种假说企图说明其降压作用,如血浆容量和细胞外液容积的减少,以及机体钠的丧失等。本文报导以双氢克尿塞治疗20例高血压病中测定循环血容量的结果,目的在于观察后者的变化与降压效果的关系。
Since the application of the diabetes drugs in the clinical treatment of hypertension, whether used alone or in combination with other antihypertensive drugs have significant antihypertensive capacity; and easy to take, with few side effects, it has become a widely used Antihypertensive drugs. However, its antihypertensive mechanism remains to be elucidated. There are several hypotheses attempting to demonstrate its antihypertensive effects, such as a decrease in plasma volume and extracellular fluid volume, and loss of sodium in the body. This article reports the results of hydrochlorothiazide in the treatment of 20 cases of hypertension in the determination of circulating blood volume results, the purpose is to observe the latter changes and the relationship between antihypertensive effect.