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目的探讨胎膜早破(PPROM)孕妇血清NO水平及羊膜细胞凋亡变化。方法将52例PPROM孕妇作为研究对象,随机抽取孕足月完好胎膜孕妇63例为正常对照组。对其血清NO水平、羊膜细胞凋亡指数(AI)及羊膜组织的中性粒细胞进行比较。结果 PPROM组孕妇羊膜炎发生率、血清NO水平、胎膜细胞凋亡指数明显高于对照组,差异有统计学意义(P<0.05)。结论 PPROM与血清NO水平及羊膜细胞凋亡密切相关。
Objective To investigate the changes of serum NO level and amniotic cell apoptosis in pregnant women with premature rupture of membranes (PPROM). Methods Fifty-two PPROM pregnant women were selected as study subjects, and 63 pregnant women with intact pregnancies were randomly selected as normal control group. The level of serum NO, amniotic cell apoptosis index (AI) and amniotic tissue neutrophils were compared. Results The incidence of amniolitis, serum NO level and apoptosis index in PPROM group were significantly higher than those in control group (P <0.05). Conclusion PPROM is closely related to serum NO level and amniotic cell apoptosis.