,Molecular properties,functions,and potential applications of NAD kinases

• 作 者: Feng Shi Yongfu Li Ye Li Xiaoyuan Wang
• 机 构: State Key Laboratory of Food Science and Technology,Jiangnan University,Wuxi 214122,China“,”School o
• 出 处: 生物化学与生物物理学报（英文版）
• 发表日期: 2009年5期
• 关键词: NAD kinase NAD+/NADH NADP+/NADPH coenzyme metabolism

NAD kinase catalyzes the phosphorylation of NAD(H)to form NADP(H),using ATP as phosphoryl donor.It is the only key enzyme leading to the de novo NADP+/NADPH biosynthesis.Coenzymes such as NAD(H)and NADP(H)are known for their important functions.Recent studies have partially demonstrated that NAD kinase plays a crucial role in the regulation of NAD(H)/NADP(H)conversion.Here,the molecular properties,physiologic functions,and potential applications of NAD kinase are discussed.