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红霉素和地高辛都可以引起胃肠道副作用。然而,在少数患者中,红霉素可致血液地高辛浓度成倍地升高,且又常把胃肠道症状误认为是红霉素引起。本文报道1例患者,其出现的地高辛中毒性心脏和胃肠道并发症与同时使用红霉素治疗有关。患者为1例伴有心动过缓的59岁妇女,因上呼吸道感染口服红霉素500mg,1天3次,4天后连续2天出现恶心和呕吐。患者自1972年作二尖瓣替换后,一直使用地高辛(0.25mg/天)和法华令(抗凝血药)作维持治疗。早在18个月前,其血清地高辛浓度已达2.3nmol/L(治疗范围1.0～2.8nmol/L),经检查发现心率不规则(40～50次/分),心脏肥大,心
Erythromycin and digoxin can cause gastrointestinal side effects. However, in a small number of patients, erythromycin can cause a doubling of the blood digoxin concentration, and the gastrointestinal symptoms are often mistaken for erythromycin. This article reports 1 patient, the occurrence of digoxin toxic heart and gastrointestinal complications associated with the use of erythromycin. One patient with a bradycardia was a 59-year-old woman who received oral erythromycin 500 mg three times a day for upper respiratory tract infection and nausea and vomiting for two consecutive days after 4 days. Patients have been treated with digoxin (0.25 mg / day) and warfarin (anticoagulant) for maintenance after they have undergone mitral valve replacement in 1972. As early as 18 months ago, the concentration of serum digoxin has reached 2.3nmol / L (treatment range 1.0 ~ 2.8nmol / L), the examination revealed irregular heart rate (40 ~ 50 beats / min), cardiac hypertrophy, heart