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选取2014年3月~2016年3月DM及DN患者各100例。研究对象标准饮食3 d后,次晨空腹抽血检测FPG、FIns、HbA_(1c)、CRP水平。然后将DN组再分为2组,胰岛素组给予单一胰岛素治疗,联合治疗组在胰岛素组基础上联合吡格列酮。治疗3月后。结果:DN组CRP水平、FPG及PPG及HbA_(1c),高于DM组(P<0.05);DN组FIns水平低于DM组(P<0.05)。治疗3个月后,联合治疗组CRP、FPG、PPG及HbA_(1c)水平,低于胰岛素组(P<0.05),3个月后FIns,高于胰岛素组(P<0.05)。结论:T_2DM并发微血管病变炎症反应发挥重要的作用,且与2R有关。
100 patients with DM and DN were selected from March 2014 to March 2016. After 3 days of standard diet, FPG, FIns, HbA_ (1c) and CRP levels were measured in the next morning fasting blood. The DN group was further divided into two groups, the insulin group received single insulin treatment, and the combination therapy group combined with pioglitazone on the basis of insulin group. After 3 months of treatment. Results: The levels of CRP, FPG, PPG and HbA 1c in DN group were higher than those in DM group (P <0.05). The level of FIns in DN group was lower than that in DM group (P <0.05). After 3 months of treatment, the levels of CRP, FPG, PPG and HbA 1c in the combined treatment group were lower than those in the insulin group (P <0.05). After 3 months, the levels of FIns in the combination group were higher than those in the insulin group (P <0.05). CONCLUSION: T 2DM plays an important role in the inflammatory reaction of microangiopathy and is related to 2R.