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目的探讨复方米非司酮配伍米索前列醇终止早孕的临床疗效。方法选取晋中市榆次区妇幼保健院2012年8月—2014年8月收治的100例早期妊娠孕妇,根据其意愿分为观察组与对照组,各50例。观察组给予复方米非司酮配伍米索前列醇流产,对照组给予米非司酮配伍米索前列醇流产,比较两组孕妇完全流产率、孕囊排出时间、流产后阴道流血时间、转经时间以及不良反应发生情况、刮宫标本病理学检查结果。结果观察组孕妇完全流产率高于对照组,孕囊排出时间、流产后阴道流血时间、转经时间短于对照组,不良反应发生率低于对照组,绒毛坏死程度轻于对照组,差异有统计学意义(P<0.05)。结论复方米非司酮配伍米索前列醇终止早孕疗效显著,能够实现完全流产,同时药物安全性高。
Objective To investigate the clinical efficacy of compound mifepristone and misoprostol for termination of early pregnancy. Methods 100 pregnant women of early pregnancy who were treated in Yuci District Maternity and Child Care Hospital of Jinzhong City from August 2012 to August 2014 were divided into observation group and control group according to their wishes. The observation group was given mifepristone combined with misoprostol miscarriage, the control group was given mifepristone with misoprostol miscarriage. The complete abortion rate, gestational sac excretion time, vaginal bleeding time after abortion were compared between the two groups Time and adverse reactions, curettage specimen pathological examination results. Results The abortion rate of pregnant women in the observation group was higher than that in the control group. The gestational sac excretion time, vaginal bleeding time after abortion, transit time were shorter than those in the control group, the incidence of adverse reactions was lower than that in the control group, and the degree of villus necrosis was lower than that in the control group Statistical significance (P <0.05). Conclusion The combination of mifepristone and misoprostol has a significant curative effect in terminating early pregnancy, which can lead to complete abortion and high drug safety.