论文部分内容阅读
Eight rare earth metal (Ⅲ) complexes with 2-(((4,6-dimethyl)-2-pyrimidinyl)thio)-acetic acid, LnL_3·nH_2O [HL=2-(((4,6-dimethyl)-2-pyrimidinyl)thio)-acetic acid; Ln=La, Ce, Pr, Nd, Sm Eu, Gd, Tb; n=4 or 5], were prepared and characterized by elemental analysis, complexometric titration, thermal analysis, conductivity, IR and 1H-NMR. The results reveal that carboxyl group of the ligand coordinates with rare earth ions in bidentate mode after deprotonated. The water molecules exist as crystal water in the complexes. The anti-tumour activities of HL and some complexes were tested by both the MTT and SRB methods. The results show that the suppression ratios of some complexes against the tested tumour cells (HL-60 human leukemia cell lines, BGC-823 human gastric carcinoma cell lines, hela human cervix adenocarcinoma cell lines and Bel-7402 human hepatic carcinoma cell lines) are superior to HL.
Eight rare earth metal (Ⅲ) complexes with 2 - ((4,6-dimethyl) -2-pyrimidinyl) thio) -acetic acid, LnL_3 · nH_2O [HL = Ln = La, Ce, Pr, Nd, SmEu, Gd, Tb; n = 4 or 5], were prepared and characterized by elemental analysis, complexometric titration, thermal analysis, conductivity, IR and 1H-NMR. The results reveal the carboxyl group of the ligand coordinates with rare earth ions in bidentate mode after deprotonated. The water molecules exist as crystal water in the complexes. The anti-tumor activities of HL and some complexes were tested by both the results show that the suppression ratio of some complexes against the tested tumor cells (HL-60 human leukemia cell lines, BGC-823 human gastric carcinoma cell lines, hela human cervix adenocarcinoma cell lines and Bel-7402 human hepatic carcinoma cell lines) are superior to HL.