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目的探讨腹部外科手术后MODS患者内分泌及免疫功能的改变。方法检测MODS组20例及非MODS组34例患者术前及术后1、3、7d外周血清TNF,IL-6,T3,T4,rT3,FT3,FT4,GH,C3,C4,CRP水平,进行统计学分析。结果MODS患者内分泌及免疫功能的改变大于非MODS患者。T3,T4,FT3,FT4较非MODS组显著性下降(P<0.05),rT3,GH较非MODS组显著性升高(P<0.05)。TNF,IL-6,CRP较非MODS组显著性升高(P<0.05)。C3,C4较非MODS组显著性下降(P<0.05)。结论MODS状态下出现的内环境紊乱,不仅有免疫失衡,神经及内分泌功能也有不同程度的改变。
Objective To investigate the changes of endocrine and immune function in patients with MODS after abdominal surgery. Methods The levels of TNF, IL-6, T3, T4, rT3, FT3, FT4, GH, C3, C4 and CRP in peripheral blood of 20 patients in MODS group and 34 patients in non- Statistical analysis. Results The changes of endocrine and immune function in MODS patients were more than those in non-MODS patients. T3, T4, FT3 and FT4 decreased significantly (P <0.05), while rT3 and GH increased significantly (P <0.05) than non-MODS group. TNF, IL-6 and CRP were significantly higher than those in non-MODS group (P <0.05). C3, C4 significantly decreased compared with non-MODS group (P <0.05). Conclusions The internal environment disorders that occur in MODS state not only have immune imbalance, but also have different degrees of nerve and endocrine function.